cardiac, hepatic, hormonal, irritant and purgative effects, and arange of toxicities. Some of the potential adverse effects of the herbal ingredients which are the subject of the 152 monographs are listed in Table 2. For further detailed information, including literature references, the reader should consult individual monographs. The following few examples are illustrative of some of the adverse effects caused by herbal ingredients.Comfrey, coltsfoot Hepatotoxic reactions have been documented for comfrey and coltsfoot. Both of these herbal ingredients contain pyrrolizidine alkaloids,
compounds known to be hepatotoxic. However, it was later reported that the reaction documented for coltsfoot may have in fact involved a herbal tea containing a Senecio species rather than coltsfoot.(73) The Senecio genus is characterised by its pyrrolizidine alkaloid constituents.click here for download
