PHARMACEUTICAL PREFORMULATION

This book addresses problems and solutions of formulation and preformulation with which I have concerned myself for 34 years. When I was employed in the pharmaceutical industry I worked at functions, in the 1960's, which were the precursurs of preformulation, and my early publications dealt with such matters. In the following decades advances have been made in methodology and the realm of preformulation has grown. Theory and the way in which problems are viewed have also undergone change.
The text deals with the pharmaceutical aspects of preformulation, not the synthetic nor the analytical aspects. It takes it vantage point at the point in time when the pharmaceutical preformulator first obtains a sample of the drug substance, and it explores the physical, chemical and technological aspects that are needed for a full exploration of the potential advantages and disadvantages of the drug substance. It is only through the understanding of underlying principles that adequate exploration can be carried out.The ''fast-track" approach to drug development advocated by many pharmaceutical companies today is an unhealthy click here for download