PHARMACEUTICAL PREFORMULATION

This book addresses problems and solutions of formulation and preformulation with which I have concerned myself for 34 years. When I was employed in the pharmaceutical industry I worked at functions, in the 1960's, which were the precursurs of preformulation, and my early publications dealt with such matters. In the following decades advances have been made in methodology and the realm of preformulation has grown. Theory and the way in which problems are viewed have also undergone change.
The text deals with the pharmaceutical aspects of preformulation, not the synthetic nor the analytical aspects. It takes it vantage point at the point in time when the pharmaceutical preformulator first obtains a sample of the drug substance, and it explores the physical, chemical and technological aspects that are needed for a full exploration of the potential advantages and disadvantages of the drug substance. It is only through the understanding of underlying principles that adequate exploration can be carried out.The ''fast-track" approach to drug development advocated by many pharmaceutical companies today is an unhealthy click here for download

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PHARMACEUTICAL COMPOUNDING AND DISPENSING

Accurate and effective pharmaceutical formulation is a key skill which must be mastered by all student pharmacists and pharmaceutical technicians. This book is intended to be a guide to assist the student compounder in practising exercises relating to the key dosage forms encountered within extemporaneous dispensing.The book has been designed as a stand-alone revision text and summarises the key points behind the manufacture of common extemporaneous dosage forms, along with a series of worked examples and questions (with answers) for students to use for selflearning.
When a prescription is received for an extemporaneous product there are a number of considerations to be made prior to dispensing. Within each chapter, the worked examples section will take a number of different preparations and expand on their compounding using the following subheadings. click here for download

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ENCYCLOPEDIA OF PHARMACEUTICAL TECHNOLOGY

Blow-Fill-Seal (BFS) technology was developed in the early 1960s and was initially
used for filling many liquid product categories, for example, nonsterile medical devices,foods, and cosmetics. The technology has been developed to an extent that today BFS systems are used to asepticallyproduce sterile pharmaceutical products such as respiratory solutions, ophthalmics, and wound-care products throughout the world.The BFS technology is an advanced aseptic processing technique which allows plastic containers to be formed by means of molded extruded polymer granules, filled, and sealed in one continuous process. This differs from conventional aseptic processing where container formation, preparation, and sterilization, and container filling and closure are all separate processes click here for download

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APPLIED PHARMACEUTICAL PRACTICE

The supply of medicines is a basic function of pharmacists and pharmacy technicians. With the advent of clinical pharmacy and the introduction of ‘new roles’ for pharmacists, the content of pharmaceutical education has altered to reflect these additions. However, the supply of medicines remains a key component of the role of pharmacy within modern healthcare and, therefore, it is vital that all pharmacists and pharmacy technicians are competent in medicines supply.
This text has been designed to guide the student pharmacist or pharmacy technician through the main stages involved in safe and effective medicines supply. The purpose of the book is to provide student pharmacists with a core reference text to accompany the compulsory dispensing courses found in all MPharm programmes. Additionally, it will be of equal value for student pharmacy technicians during their educational courses.To guide the reader through the different topics relating to medicines supply, this book has been divided into a number of different chapters. clik here for download

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HANDBOOK OF PREBIOTIC

This handbook reviews the latest developments in prebiotics, which are popular functional food ingredients designed to improve human or animal health by mediating activities of gut microflora. Currently, there is much debate on what prebiotics actually are, where they come from, and what they can do. In this book, a range of leading scientists in the field have provided their views in this rapidly advancing area of nutrition and microbiology. The approach is to begin a particular section of the book with a general overview on the area of interest. Following that, more specific comments on prebiotic influences appear. The authors are experts in their particular areas and all have been encouraged to give a balanced view of the current situations.click here for download

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HERBAL MEDICINE 3RD EDITION

cardiac, hepatic, hormonal, irritant and purgative effects, and arange of toxicities. Some of the potential adverse effects of the herbal ingredients which are the subject of the 152 monographs are listed in Table 2. For further detailed information, including literature references, the reader should consult individual monographs. The following few examples are illustrative of some of the adverse effects caused by herbal ingredients.Comfrey, coltsfoot Hepatotoxic reactions have been documented for comfrey and coltsfoot. Both of these herbal ingredients contain pyrrolizidine alkaloids, compounds known to be hepatotoxic. However, it was later reported that the reaction documented for coltsfoot may have in fact involved a herbal tea containing a Senecio species rather than coltsfoot.(73) The Senecio genus is characterised by its pyrrolizidine alkaloid constituents.click here for download

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PHARMACIST HANDBOOK

An important skill in the pharmacist's professional life is the ability to communicate accurately and comprehensibly. This skill is especially critical when one considers the audiences that the pharmacist communicates with. The pharmacist is in a unique position, and has a real responsibility, to understand the language of both the professional and lay audiences. It is through this understanding that the pharmacist can help patients to realize the best possible benefits fiom their therapies.clik here for download

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SAFETY PHARMACOLOGY IN PHARMACEUTICAL

Safety pharmacology is the evaluation and study of the pharmacological effects of a potential drug that are unrelated to the desired therapeutic effect and, therefore, may present a hazard—particularly in individuals who already have one or more compromised or limited organ system functions. Unlike other nonclinical evaluations of a drug’s safety, these evaluations are usually conducted at doses close to the intended clinical dose. Recent International Conference on Harmonization (ICH) guidelines,followed by versions by national regulatory authorities including those of the U.S. Food and Drug Administration (FDA), have made such evaluations mandatory before a potential drug is introduced into humans—while also failing to provide clear guidance as to how the requirements are to be met click here for download

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EBOOK BRITISH PHARMACOPOEIA 2009

"The British Pharmacopoeia" ("BP") 2009 is the authoritative, current collection of standards for UK medicinal substances and the official source of all UK pharmaceutical quality standards. It is an essential reference for anyone involved in pharmaceutical research, development, manufacture and testing, and plays a vital role in ensuring that all medicinal substances on the UK market meet standards of safety, quality and efficacy.The "BP" comprises monographs, which set out the mandatory standards for active substances, excipients and formulated preparations, together with supporting General Notices, Appendices (test methods, reagents, etc) and Reference Spectra.click here for dowmload (source:pharmatext.org)

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CONTEMPORARY DRUGS SYNTHESIS

Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and .development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students click here for download

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