IMMUNOLOGY AND IMMUNOPHATOGENESIS OF MALARIA

Malaria is still a major global health problem, killing more than one million people every year. Almost all of these deaths are caused by Plasmodium falciparum, one of the four species of malaria parasites infecting humans. This high burden of mortality falls heavily on sub-Saharan Africa, where over 90% of these deaths are thought to occur, and 5% of children die before the age of 5 years. The death toll from malaria is still growing, with malariaspecificmortality in youngAfrican children estimated to have doubled during the last 20 years. This increase has been associated with drug resistance of the parasite, spread of insecticide-resistant mosquitoes, poverty, social and political upheaval, and lack of effective vaccines. Failure of the host to control a malaria infection is in part related to the complexity of the parasite and the interaction with the immune system of the host. Although there is now considerably more investment in malaria research, and there are encouraging signs in vaccine development, we are a long way from understanding the nature and control of protective immunity or the pathological consequences of the host’s response to Plasmodium.With themajor advances in knowledge in basicimmunology, inflammation, and the genomic information on the host, vector and parasite, we are nowin a position to elucidate the key unknowns in the immune response to malaria clik here for download ebook (source:medicalbookforeveryone)

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MANAGEMENT OF SEVERE MALARIA

The World Health Organization was established in 1948 as a specialized agency of the United Nations serving as the directing and coordinating authority for international health matters and public health. One of WHO’s constitutional functions is to provide objective and reliable information and advice in the field of human health, a responsibility that it fulfils in part through its extensive programme of publications The Organization seeks through its publications to support national health strategies and address the most pressing public health concerns of populations around the world. To respond to the needs of Member States at all levels of development, WHO publishes practical manuals, handbooks and training material for specific categories of health workers; internationally applicable guidelines and standards; reviews and analyses of health policies, programmes and research; and state-of-the-art consensus reports that offer technical advice and recommendations for decision-makers
workers; internationally applicable guidelines and standards; reviews and analyses of health policies, programmes and research; and state-of-the-art consensus reports that offer technical advice and recommendations for decision-makers. These books are closely tied to the Organization’s priority activities, encompassing disease prevention and control, the development of equitable health systems based on primary health care, and health promotion for individuals and communities. Progress towards better health for all also demands the global dissemination and exchange of information that draws on the knowledge and experience of all WHO’s Member countries and the collaboration of world leaders in public health and the biomedical sciences.klik here for download ebook (source: medicalbook for every one)

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